Title of project

Gender affirming hormone therapy and physical health in transgender persons

Abstract

Aim: To investigate baseline and prospective physical health outcomes associated with genderaffirming hormone therapy (GAHT) in transgender persons.

Background: Gender-affirming care aims to alleviate gender dysphoria and improve mental health. There is a dramatic increase in referrals for GAHT, highlighting the need for evidence-based treatment. While GAHT is vital for aligning physical appearance with gender identity, it may also pose risks for physical health, including cardiovascular and respiratory issues. Understanding these risks is essential for optimizing care protocols in Denmark and beyond.

Methods: The project includes a prospective audit and a clinical study. Transgender individuals attending Center for Gender Identity Odense for GAHT are enrolled in an ongoing audit that tracks clinical and patient-reported outcomes. The prospective clinical study (approved by the local ethical Committee) investigates cardiovascular disease, cardiac and lung function, muscle strength, and cardioinflammatory biomarkers before GAHT and after 1, 3, 5 and 10 years compared to controls. The goal is to identify predictors of improved of deteriorated physical health.

Ethical Considerations: With increasing attention on transgender health, particularly in younger populations, this research contributes to the understanding of GAHT’s effects on physical health to ensure safe and effective treatment and follow-up.