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PhD student Johan Onslev has received DKK 1.1 million for his PhD based on the project called ”Identification of molecular mechanisms underlying muscle glucose utilization during exercise and enhanced insulin sensitivity”

While the effects of exercise on glucose uptake and insulin sensitivity are positive and well known, the underlying molecular mechanisms and metabolic shifts that drive these changes in muscles have not yet been well described. Therefore, the purpose of the experiment is to uncover the cellular signalling and the metabolic shifts that underlie the acute effect of exercise on glucose uptake and insulin sensitivity in skeletal muscle. The experiment will be performed on both healthy and insulin-resistant test subjects in order to investigate whether these phenomena are the same in the two groups. The study's insight into human skeletal muscle in connection with acute work and insulin sensitivity has the potential to uncover as yet unknown cellular mechanisms that can be used in developing new medications in the fight against impaired insulin sensitivity, type 2 diabetes and late-stage diabetic complications. Adviser: Professor Jørgen Wojtaszewski.

For more information about the project contact Johan Onslev or read a longer summary here.